Linkage Disequilibrium Decay and Haplotype Block Structure in the Pig
نویسندگان
چکیده
منابع مشابه
Linkage disequilibrium decay and haplotype block structure in the pig.
Linkage disequilibrium (LD) may reveal much about domestication and breed history. An investigation was conducted, to analyze the extent of LD, haploblock partitioning, and haplotype diversity within haploblocks across several pig breeds from China and Europe and in European wild boar. In total, 371 single-nucleotide-polymorphisms located in three genomic regions were genotyped. The extent of L...
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Linkage disequilibrium (LD) across the genome is critical information for association studies and genomic selection because it determines the number of SNP that should be used for a successful association analysis and genomic selection. Linkage disequilibrium also influences the accuracy of genomic breeding values. Some studies have demonstrated that SNP in strong LD are organized into discrete...
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Linkage disequilibrium has become an important tool for fine-scale mapping. We argue that in order to understand the pattern of association between alleles at different loci, as well as DNA sequence polymorphism, it is useful first to consider the underlying genealogy of the chromosomes. The stochastic process known as the coalescent provides an extremely convenient way of modeling such genealo...
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Single-marker linkage-disequilibrium (LD) methods cannot fully describe disequilibrium in an entire chromosomal region surrounding a disease allele. With the advent of myriad tightly linked microsatellite markers, we have an opportunity to extend LD analysis from single markers to multiple-marker haplotypes. Haplotype analysis has increased statistical power to disclose the presence of a diseas...
متن کاملLinkage disequilibrium in the domesticated pig.
This study investigated the extent of linkage disequilibrium (LD) in two genomic regions (on chromosomes 4 and 7) in five populations of domesticated pigs. LD was measured with D' and tested for significance with the Fisher exact test. Effects of genetic (linkage) distance, chromosome, population, and their interactions on D' were tested both through a linear model analysis of covariance and by...
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ژورنال
عنوان ژورنال: Genetics
سال: 2008
ISSN: 1943-2631
DOI: 10.1534/genetics.107.084277